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A detailed scientific study of the biodegradability of our sol-gel silica particles was published online in the Journal of Sol-Gel Science and Technology. This study details the dissolution in-vitro, using a USP4 flow-through dissolution tester, of a range of our silica matrices use for healthcare applications. In the open configuration, which most closely models in-vivo conditions, the particles dissolved rapidly at pH 7.4, with a rate dependent on the surface area and media flow rate. Addition of serum proteins acted to slow dissolution by 20 ? 30 %, suggesting a slower degradation in-vivo.  Silica microparticles administered for controlled release drug delivery would therefore be expected to be eliminated relatively rapidly from the body, depending on the sample size and local fluid flow conditions.

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